Chemodivergence between Electrophiles in Cross‐Coupling Reactions

Chemodivergent cross-couplings are those in which either one of two (or more) potentially reactive functional groups can be made to react based on choice conditions. In particular, this review focuses involving different (pseudo)halides that compete for the role electrophilic coupling partner. The discussion is primarily organized by pairs electrophiles including chloride vs. triflate, bromide tosylate, and halide halide. Some common themes emerge regarding origin selectivity control. These include catalyst ligation state solvent polarity or coordinating ability. However, many cases, further systematic studies will necessary deconvolute influences metal identity, ligand, solvent, additives, nucleophilic partner, other factors chemoselectivity.